Carboxylic acids and derivatives
Cayman Chemical Simvastatin sodium salt
An HMG-CoA reductase inhibitor (Ki = 0.12 nM); reduces plasma cholesterol levels in rats and dogs at 1.2 and 8 mg/kg, respectively; suppresses TNF-induced NF-κB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid leukemia cells; inhibits GPX4, increases MDA levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells
Apexbio Technology LLC Cinepazide maleate 26328-04-1 10mM (in 1mL DMSO)
Cinepazide maleate (CAS 26328-04-1) is the maleate salt of cinepazide classified as a vasodilatory agent It exerts its effects primarily through inhibition of calcium influx in vascular smooth muscle cells leading to vessel relaxation and increased blood flow This mechanism is associated with reduced peripheral resistance and enhanced microcirculation Cinepazide maleate has been utilized in research exploring vascular tone modulation cerebral blood flow and ischemia models providing a tool for investigating mechanisms of vasodilation and circulatory disorders in preclinical settings
Apexbio Technology LLC NB-598 Maleate 155294-62-5 10mg
NB-598 Maleate is a small-molecule inhibitor targeting squalene epoxidase (SE) an essential enzyme in cholesterol biosynthesis It is designed to inhibit SE thereby disrupting the oxygenation of squalene and affecting downstream synthesis of cholesterol intermediates particularly within farnesol-dependent pathways leading to triglyceride biosynthesis NB-598 Maleate exerts its biological activity primarily through inhibition of squalene epoxidase In mouse pancreatic islet models NB-598 Maleate reduces insulin secretion under both basal and glucose-stimulated conditions Additionally this compound inhibits calcium voltage-dependent (CaV) ion channels in cellular assays Based on these pharmacological properties NB-598 Maleate holds research potential in studying cholesterol biosynthesis pathways lipid metabolism insulin regulation and the physiological role of CaV channels
Cayman Chemical Pravastatin sodium salt
A potent HMG-CoA reductase inhibitor (Ki = 2.3 nM); reduces total plasma cholesterol levels by 29% in dogs at 20 mg/kg per day for five weeks
Pfanstiehl Inc Dramamine Active EDGT (D-135) 5kg pack API, active pharmaceutical ingredient- CAS: 523-87-5
Dramamine Active EDGT (D-135) 5kg pack API, active pharmaceutical ingredient- CAS: 523-87-5
Sigma Aldrich Fine Chemicals Biosciences Disodium succinate >=98% | 150-90-3 | MFCD00002790 | 10KG
Disodium succinate >=98% | Purity: >=98% | Mol Wt: 162.05 | 150-90-3 | MFCD00002790 | 10KG
Sigma Aldrich Fine Chemicals Biosciences Disodium succinate >=98% | 150-90-3 | MFCD00002790 |
Disodium succinate >=98% | Purity: >=98% | Mol Wt: 162.05 | 150-90-3 | MFCD00002790 |
Apexbio Technology LLC Flupirtine maleate 75507-68-5 100mg
Flupirtine maleate (CAS 75507-68-5) is a non-opioid analgesic compound characterized by its modulatory effects on neuronal excitability It acts primarily by opening neuronal potassium channels leading to membrane stabilization and reduced excitatory neurotransmission Additionally flupirtine exerts indirect antagonism of N-methyl-D-aspartate (NMDA) receptors which contributes to its analgesic and muscle relaxant effects Due to this dual mechanism flupirtine maleate is utilized in research focusing on pain modulation neuroprotection and the investigation of NMDA receptor-mediated pathways
Medchemexpress LLC Omigapil maleate | 200189-97-5 | 99.8% | 391.42 | 5 MG
Omigapil maleate (CGP3466B) is an orally active GAPDH nitrosylation inhibitor with potential for research into Alzheimer's disease and congenital muscular dystrophy (CMD). It is also an apoptosis inhibitor and a click chemistry reagent.
- Abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice
- Acts as an apoptosis inhibitor
- Can be used for research of congenital muscular dystrophy (CMD)
- Functions as a click chemistry reagent containing an Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Dizocilpine maleate | 77086-22-7 | C20H19NO4 | 1 ML
Dizocilpine maleate (MK-801 maleate) is a potent, selective, and non-competitive antagonist of the NMDA receptor. It has a Kd of 37.2 nM in rat brain membranes and causes a progressive, long-lasting blockade of N-Me-D-Asp and NMDA-induced currents.
- Potent, selective, and non-competitive NMDA receptor antagonist
- Blocks NMDA-activated single-channel activity
- Inhibits activation of microglia induced by LPS
- Reduces microglial TNF-α output
- Can be used to induce schizophrenia models
Medchemexpress LLC Sumanirole maleate | 179386-44-8 | 99.8% | C15H17N3O5 | 50 MG
Sumanirole maleate is a highly selective full agonist of the D2 receptor, exhibiting an ED50 of approximately 46 nM. This compound is significant in the study of Parkinson's disease and restless leg syndrome. It serves as a valuable research tool for investigating neurobiological mechanisms that are specifically linked to dopamine D2 receptor activity.
- Highly selective full agonist of the D2 receptor.
- Involved in research concerning Parkinson's disease.
- Used in the study of restless leg syndrome.
- Aids in identifying neurobiological mechanisms dependent on D2 receptor linkage.